Autoimmunity in dilated cardiomyopathy and the major histocompatibility complex.

  title={Autoimmunity in dilated cardiomyopathy and the major histocompatibility complex.},
  author={Constantinos J. Limas},
  journal={International journal of cardiology},
  volume={54 2},
Autoimmune mechanisms are likely to participate in the pathogenesis of a subgroup of dilated cardiomyopathy. These mechanisms involve the elaboration of autoantibodies against cardiac proteins as well as abnormal lymphocyte regulation. The presence of autoantibodies against beta-adrenoceptors correlates with the human leukocyte antigen (HLA)-DR4/1 phenotypes and specific T-cell receptor haplotypes. In addition, histidine at position 36 of the HLA-DQ beta 1 gene is associated with the presence… CONTINUE READING
Highly Cited
This paper has 42 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 17 extracted citations