Autoimmunity in dilated cardiomyopathy and the major histocompatibility complex.

@article{Limas1996AutoimmunityID,
  title={Autoimmunity in dilated cardiomyopathy and the major histocompatibility complex.},
  author={Constantinos J. Limas},
  journal={International journal of cardiology},
  year={1996},
  volume={54 2},
  pages={
          113-6
        }
}
Autoimmune mechanisms are likely to participate in the pathogenesis of a subgroup of dilated cardiomyopathy. These mechanisms involve the elaboration of autoantibodies against cardiac proteins as well as abnormal lymphocyte regulation. The presence of autoantibodies against beta-adrenoceptors correlates with the human leukocyte antigen (HLA)-DR4/1 phenotypes and specific T-cell receptor haplotypes. In addition, histidine at position 36 of the HLA-DQ beta 1 gene is associated with the presence… CONTINUE READING
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