Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient.

@article{CunhaNeto1996AutoimmunityIC,
  title={Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient.},
  author={Edecio Cunha-Neto and V. Coelho and Luiza Guilherme and Alfredo In{\'a}cio Fiorelli and N. Stolf and Jorge Agle Kalil},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 8},
  pages={1709-12}
}
Heart tissue destruction in chronic Chagas' disease cardiomyopathy (CCC) may be caused by autoimmune recognition of heart tissue by a mononuclear cell infiltrate decades after Trypanosoma cruzi infection. Indirect evidence suggests there is molecular mimicry between T. cruzi and heart tissue. In murine models of CCC, antibodies and CD4+ T cells recognize myosin, the major heart protein. We recently identified a heart-specific epitope of cardiac myosin heavy chain (residues 1442-1447, AAALDK… CONTINUE READING

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Correlation between T. cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: light microscopy and immunohistochemical findings

  • M. L. Higuchi, T. De Brito, +4 authors F. Pileggi
  • Cardiovasc. Pathol
  • 1993
1 Excerpt

Anti - CD 4 treatment abrogates rejection and re - estabilishes long - term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi

  • R. Moliterno, V. Coelho, +6 authors J. Kalil
  • J . Exp . Med .
  • 1992

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