Autoimmunity due to molecular mimicry as a cause of neurological disease

  title={Autoimmunity due to molecular mimicry as a cause of neurological disease},
  author={Michael C. Levin and Sang Min Lee and Franck Kalume and Yvette Morcos and F. Curtis Dohan and Karen A. Hasty and J. C. Callaway and Joseph Raymond Zunt and Dominic M. Desiderio and John M. Stuart},
  journal={Nature Medicine},
One hypothesis that couples infection with autoimmune disease is molecular mimicry. Molecular mimicry is characterized by an immune response to an environmental agent that cross-reacts with a host antigen, resulting in disease. This hypothesis has been implicated in the pathogenesis of diabetes, lupus and multiple sclerosis (MS). There is limited direct evidence linking causative agents with pathogenic immune reactions in these diseases. Our study establishes a clear link between viral… CONTINUE READING