Autoimmunity and tumor immunity induced by immune responses to mutations in self

@article{Engelhorn2006AutoimmunityAT,
  title={Autoimmunity and tumor immunity induced by immune responses to mutations in self},
  author={Manuel E. Engelhorn and Jose Guevara-patino and Gabriele Noffz and Andrea T. Hooper and Olivia Lou and Jason S. Gold and Barry J. Kappel and Alan N. Houghton},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={198-206}
}
Little is known about the consequences of immune recognition of mutated gene products, despite their potential relevance to autoimmunity and tumor immunity. To identify mutations that induce immunity, here we have developed a systematic approach in which combinatorial DNA libraries encoding large numbers of random mutations in two syngeneic tyrosinase-related proteins are used to immunize black mice. We show that the libraries of mutated DNA induce autoimmune hypopigmentation and tumor immunity… CONTINUE READING

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