Autoimmunity and microbiota

  title={Autoimmunity and microbiota},
  author={Alexander V Chervonsky},
  booktitle={Journal of Translational Medicine},
Environment (physical insults, toxins, nutrition and microorganisms) influences development of autoimmune diseases. Pathogenic, pathobiotic and commensal microorganisms contribute to disease progression in genetically susceptible hosts. Germ-free animals or defined-microbiota colonized animals are valuable tools for understanding microbial influences on autoimmunity, especially if they could be genetically modified. Type 1 diabetes (T1D) susceptible NOD mice were used as an autoimmunity model… CONTINUE READING