Autoimmunity and lymphoma: is mantle cell lymphoma a mistake of the receptor editing mechanism?

@article{GarcaMuoz2009AutoimmunityAL,
  title={Autoimmunity and lymphoma: is mantle cell lymphoma a mistake of the receptor editing mechanism?},
  author={Ricardo Garc{\'i}a-Mu{\~n}oz and C. Guti{\'e}rrez Panizo and Maurizio Bendandi and Luis Llorente},
  journal={Leukemia research},
  year={2009},
  volume={33 11},
  pages={1437-9}
}
Mantle cell lymphoma (MCL) is an aggressive B cell malignancy, which is believed to originate from naïve B cells in the mantle zone of lymph nodes. We speculate that a possible mechanistic hypothesis for the generation of MCL is one in which receptor editing and germinal centre exclusion could be involved in the molecular development and in the display of… CONTINUE READING