Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits.

@article{Fukuda2004AutoimmunityAT,
  title={Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits.},
  author={Yukiko Fukuda and Shunichiro Miyoshi and Kojiro Tanimoto and Kenichi Oota and Kana Fujikura and Michikado Iwata and Akiyasu Baba and Yoko Hagiwara and Tsutomu Yoshikawa and Hideo Mitamura and Satoshi Ogawa},
  journal={Journal of the American College of Cardiology},
  year={2004},
  volume={43 6},
  pages={
          1090-100
        }
}
  • Yukiko Fukuda, Shunichiro Miyoshi, +8 authors Satoshi Ogawa
  • Published in
    Journal of the American…
    2004
  • Medicine
  • OBJECTIVES We sought to define the electrophysiologic property of the rabbit heart associated with autoimmunity against the second extracellular loop of the beta(1)-adrenergic receptor. BACKGROUND Sudden death of patients with cardiomyopathy, probably due to lethal ventricular arrhythmias, can be predicted by the presence of autoantibodies against the second extracellular loop of the beta(1)-adrenergic receptor. METHODS Rabbits were immunized by repetitive subcutaneous administration of a… CONTINUE READING

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