Autoimmunity against myelin oligodendrocyte glycoprotein is dispensable for the initiation although essential for the progression of chronic encephalomyelitis in common marmosets.

@article{Jagessar2008AutoimmunityAM,
  title={Autoimmunity against myelin oligodendrocyte glycoprotein is dispensable for the initiation although essential for the progression of chronic encephalomyelitis in common marmosets.},
  author={S Anwar Jagessar and Paul A. Smith and Erwin L. A. Blezer and C{\'e}cile Delarasse and Danielle Pham-Dinh and Jon D Laman and Jan Niklas Bauer and Sandra Amor and Bert A 't Hart},
  journal={Journal of neuropathology and experimental neurology},
  year={2008},
  volume={67 4},
  pages={326-40}
}
To elucidate the pathogenetic significance of myelin/oligodendrocyte glycoprotein (MOG)-specific autoreactivity in a genetically and immunologically heterogeneous nonhuman primate model of multiple sclerosis, we analyzed experimental autoimmune encephalomyelitis (EAE) in the outbred common marmoset (Callithrix jacchus). One sibling each of 5 bone marrow chimeric marmoset twins was immunized with myelin derived from wild-type (WT) C57BL/6 mice (WT myelin); the other sibling was immunized with… CONTINUE READING
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