Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

  title={Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes},
  author={Maria J L Kracht and Menno van Lummel and Tatjana R. Nikolic and Antoinette M. Joosten and Sandra Laban and Arno R. van der Slik and Peter A. van Veelen and Françoise Carlotti and Eelco J. P. de Koning and Rob C Hoeben and Arnaud Zaldumbide and Bart O Roep},
  journal={Nature Medicine},
Identification of epitopes that are recognized by diabetogenic T cells and cause selective beta cell destruction in type 1 diabetes (T1D) has focused on peptides originating from native beta cell proteins. Translational errors represent a major potential source of antigenic peptides to which central immune tolerance is lacking. Here, we describe an alternative open reading frame within human insulin mRNA encoding a highly immunogenic polypeptide that is targeted by T cells in T1D patients. We… CONTINUE READING
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