Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets.

  title={Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets.},
  author={Norio Kanatsuna and Jalal Taneera and Fariba Vaziri-Sani and Nils Wierup and Helena Larsson and Ahmed J. Delli and Hanna Sk{\"a}rstrand and Alexander Balhuizen and H. P. J. Bennet and Donald F. Steiner and Carina T{\"o}rn and Malin Fex and {\AA}ke Lernmark},
  journal={The Journal of biological chemistry},
  volume={288 40},
Insulin is a major autoantigen in islet autoimmunity and progression to type 1 diabetes. It has been suggested that the insulin B-chain may be critical to insulin autoimmunity in type 1 diabetes. INS-IGF2 consists of the preproinsulin signal peptide, the insulin B-chain, and eight amino acids of the C-peptide in addition to 138 amino acids from the IGF2… CONTINUE READING