Autoimmunity: The threat within

Abstract

shown that 3′ repair exonuclease 1 (TREX1) is essential for preventing cell-intrinsic autoimmunity. Although it has been established that loss-of-function mutations in TREX1 cause the autoimmune conditions Aicardi–Goutieres syndrome and chilblain lupus, the mechanism that underlies the immunopathology of these diseases was previously unknown. Now, Stetson… (More)
DOI: 10.1038/nri2419

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