Autoimmunity: Crosstalk in RA synovia—TLR3–BAFF axis sustains B-cell activation

A key facet of the crosstalk between stromal cells and B cells in rheumatoid arthritis (RA) has been characterized in cell studies; Michele Bombardieri et al. show that signaling by BAFF (also known as TNF ligand superfamily member 13B) and Toll-like receptor 3 (TLR3) enables autoreactive B-cell activation by RA synovial fibroblasts (RASF). B cells—targets… CONTINUE READING