Autoimmune type 1 diabetes: resolved and unresolved issues.

@article{Notkins2001AutoimmuneT1,
  title={Autoimmune type 1 diabetes: resolved and unresolved issues.},
  author={Abner Louis Notkins and {\AA}ke Lernmark},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 9},
  pages={
          1247-52
        }
}
Based on the presence of autoantibodies and a strong HLA linkage, type 1 diabetes is now classified as a chronic autoimmune disease. Many issues, however, remain unresolved. Although autoantibodies to GAD65, IA-2, and insulin are clearly markers for this disease, it is not known whether they contribute to pathogenesis or are simply the response to an existing underlying destructive process. Based on extensive studies in animal models, it is thought that it is the cell-mediated immune response… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

The molecular specificity of insulin autoantibodies.

  • Diabetes/metabolism research and reviews
  • 2000
VIEW 1 EXCERPT

The world health organization international collaborative study for islet cell antibodies

A. R. Mire-Sluis, R. G. Das, Å. Lernmark
  • Diabetologia .
  • 2000
VIEW 2 EXCERPTS

Antibodies (ICA and GADA) at diagnosis of diabetes predict the subsequent need for insulin

B Littorin
  • Diabetes Care
  • 1999
VIEW 1 EXCERPT

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