Autoimmune pancreatitis: expression and cellular source of profibrotic cytokines and their receptors.

@article{Detlefsen2008AutoimmunePE,
  title={Autoimmune pancreatitis: expression and cellular source of profibrotic cytokines and their receptors.},
  author={S{\"o}nke Detlefsen and Bence Sipos and Jingbo Zhao and Asbj\orn Mohr Drewes and Guenter Kloeppel},
  journal={The American journal of surgical pathology},
  year={2008},
  volume={32 7},
  pages={986-95}
}
Chronic pancreatitis is a fibrogenic disease. In autoimmune pancreatitis (AIP), a lymphoplasmacytic infiltration is followed by fibrosis. In vitro it has been shown that pancreatic stellate cells are transformed into proliferating myofibroblasts mainly by transforming growth factor beta (TGF-beta) and platelet-derived growth factor (PDGF). We studied the expression of these profibrotic cytokines, their receptors, and their cellular sources in AIP. Pancreatic tissues from 21 patients with AIP of… CONTINUE READING

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