Autoimmune myocarditis induced by Trypanosoma cruzi.

  title={Autoimmune myocarditis induced by Trypanosoma cruzi.},
  author={A M Acosta and Charles A. Santos-Buch},
  volume={71 6},
Antiheart immune reactions have been reported in patients with Chagas' disease, and we have postulated that the observed cardiac lesions are mediated by autoimmune antiheart reactions elicited by the etiologic agent Trypanosoma cruzi. In this report, BALB/c mice infected with a low inoculum of T. cruzi developed splenic lymphocyte cytotoxicity against normal syngeneic neonatal cardiac myofibers in vitro 150 days after infection, whereas splenic lymphocytes obtained from mice at 15, 45, 90, or… CONTINUE READING