Autoimmune modulation of astrocyte-mediated homeostasis

  title={Autoimmune modulation of astrocyte-mediated homeostasis},
  author={Thomas Korn and Mahendra Rao and Tim Magnus},
  journal={NeuroMolecular Medicine},
Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their capacity to present antigen to T cells is limited and has been questioned in vivo. However, it is an evolving concept that autoimmunity in the CNS has a profound impact on… CONTINUE READING

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