Autoimmune mechanisms underlying dilated cardiomyopathy.

  title={Autoimmune mechanisms underlying dilated cardiomyopathy.},
  author={Tsutomu Yoshikawa and Akiyasu Baba and Yuji Nagatomo},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  volume={73 4},
Autoimmune abnormalities, as well as viral infection and genetic abnormalities, appear to be major predisposing factors for dilated cardiomyopathy (DCM). Abnormalities of cell-mediated immunity are mainly involved in the onset of cardiomyopathy secondary to myocarditis. However, various antimyocardial antibodies are detected in the serum of patients with DCM. The appearance of these antibodies was considered to be an epiphenomenon associated with myocyte injury resulting from myocarditis, but… CONTINUE READING