Autoimmune mechanisms as the basis for human peripartum cardiomyopathy

@article{Ansari2002AutoimmuneMA,
  title={Autoimmune mechanisms as the basis for human peripartum cardiomyopathy},
  author={Aftab A. Ansari and James D. Fett and Robert. Carraway and Ann E. Mayne and Nattawat Onlamoon and J. Bruce Sundstrom},
  journal={Clinical Reviews in Allergy \& Immunology},
  year={2002},
  volume={23},
  pages={301-324}
}
The etiology and mechanisms of pathogenesis of human peripartum cardiomyopathy (PPCM) remain unknown. The incidence and prevalence of this disease is rare in some parts of the world and more common in others. The purpose of this review is to summarize our current knowledge of the factors that have been entertained which may contribute to the pathogenesis of PPCM with special emphasis on more recent data from our laboratory that provide support to the view that this disease is an autoimmune… 
Reviewing peripartum cardiomyopathy: current state of knowledge.
TLDR
An overview on the clinical appearance and management, risk factors and potential pathophysiological mechanisms of PPCM, and pharmacological blockade of prolactin holds the promise of novel, more disease-specific therapy options.
Peripartum Cardiomyopathy: Review of the Literature
TLDR
A comprehensive updated review of PPCM is provided covering etiopathogeneses, clinical presentation and diagnosis, as well as pharmacological, perioperative and intensive care management and prognosis, while stressing areas that require further research.
Clinical and immunologic characteristics in peripartum cardiomyopathy.
An update on treatments and outcomes in peripartum cardiomyopathy.
TLDR
Therapies for chronic heart failure from PPCM are similar to those patients with nonischemic cardiomyopathy from different etiologies, however novel therapies may include bromocriptine, pentoxifylline or other potential therapies influencing the immune system.
One hundred cases of peripartum cardiomyopathy... and counting: what is going on?
Peripartum Cardiomyopathy: Moving Towards a More Central Role of Genetics#
TLDR
The direct and indirect observations on genetic susceptibility may offer new insights into the pathogenesis of PCM, however, larger studies are needed before advising routine genetic testing in these patients.
...
...

References

SHOWING 1-10 OF 53 REFERENCES
Contribution of the innate immune system to autoimmune myocarditis: a role for complement
TLDR
These findings provide a mechanism by which activated complement, a key product of the innate immune response, modulates the induction of an autoimmune disease.
Peripartum cardiomyopathy in the Hospital Albert Schweitzer District of Haiti.
TLDR
Peripartum cardiomyopathy appears to be relatively common in the Hospital Albert Schweitzer District of Haiti and a core group of patients is identified for ongoing epidemiologic and immunohematologic investigation of risk factors and potential etiologic factors.
Myocarditis and long-term survival in peripartum cardiomyopathy.
TLDR
In patients with PPCM, long-term survival is better than has been historically reported, the prevalence of myocarditis is high, and decreased left ventricular stroke work index is associated with worse clinical outcomes.
Fetal microchimerism alone does not contribute to the induction of primary biliary cirrhosis
TLDR
Results, using the more sensitive technology, showed that microchimerism is a very common event in human liver and supported the thesis that this may contribute to the induction/maintenance of fetal tolerance.
Peripartum cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) workshop recommendations and review.
TLDR
Peripartum cardiomyopathy is a rare lethal disease about which little is known and diagnosis is confined to a narrow period and requires echocardiographic evidence of left ventricular systolic dysfunction.
The genetic susceptibility to Graves' disease.
  • Y. Tomer, T. Davies
  • Biology, Medicine
    Bailliere's clinical endocrinology and metabolism
  • 1997
Gonadal steroids and immunity.
TLDR
The effects of gonadal steroids on the function of the normal immune system as well as their impact on autoimmune processes are examined and current knowledge of the cellular and molecular mechanisms by which Gonadal Steroid effects on Immunity are explored.
Peripartum heart failure: idiopathic cardiomyopathy or compounding cardiovascular events?
TLDR
The authors conclude that idiopathic peripartum cardiomyopathy is uncommon, and that in most women with periparum heart failure of obscure etiology, underlying chronic disease will be identified.
...
...