Autoimmune lymphoproliferative syndromes (ALPS): models for the study of peripheral tolerance.

@article{Fischer2000AutoimmuneLS,
  title={Autoimmune lymphoproliferative syndromes (ALPS): models for the study of peripheral tolerance.},
  author={Alain Fischer and Fr{\'e}d{\'e}ric Rieux-Laucat and Françoise le Deist},
  journal={Reviews in immunogenetics},
  year={2000},
  volume={2 1},
  pages={
          52-60
        }
}
Lymphocyte cell death is a key event in the homeostasis of the immune system. Lymphocytes can be induced to die because of exposure to toxic agents, because of cytokine withdrawal or because specific cell surface receptors are engaged by their ligands. A number of such receptors belonging to the TNF receptor have been described in the recent past. Among these, the role of the Fas ligand/receptor interaction in the induction of lymphocyte cell death has been enlightened by the study of natural… CONTINUE READING