Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive

@article{Winer2003AutoimmuneID,
  title={Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive},
  author={Shawn Winer and Hubert Tsui and Ambrose Lau and Aihua Song and Xiaomao Li and R. K. M. Cheung and Anastazia Sampson and Fatemeh Afifiyan and Alisha R. Elford and George Jackowski and Dorothy Becker and Pere Santamaria and Pamela S Ohashi and H -Michael Dosch},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={198-205}
}
Pancreatic islets of Langerhans are enveloped by peri-islet Schwann cells (pSC), which express glial fibrillary acidic protein (GFAP) and S100β. pSC-autoreactive T- and B-cell responses arise in 3- to 4-week-old diabetes-prone non-obese diabetic (NOD) mice, followed by progressive pSC destruction before detectable β-cell death. Humans with probable prediabetes generate similar autoreactivities, and autoantibodies in islet-cell autoantibody (lCA) –positive sera co-localize to pSC. Moreover, GFAP… CONTINUE READING
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