Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells.

@article{Sarukhn1999AutoimmuneIA,
  title={Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells.},
  author={Adelaida Sarukh{\'a}n and Oskar Lechner and Harald von Boehmer},
  journal={European journal of immunology},
  year={1999},
  volume={29 10},
  pages={3410-6}
}
Autoimmune diabetes develops following recognition of organ-specific antigens by T cells. The disease begins with peri-islet infiltration by mononuclear cells, proceeds with insulitis and becomes manifest with destruction of insulin-producing islet beta-cells. T cells are necessary to induce insulitis and diabetes, but it is not clear by what mechanisms they can do so, i. e. whether the T cells need to make antigen-specific contact with the beta-cell or whether other interactions are sufficient… CONTINUE READING

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