Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ.

@article{Ichii2008AutoimmuneGI,
  title={Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ.},
  author={O Ichii and Akihiro Konno and Naosuke Sasaki and Daiji Endoh and Yoshinori Hashimoto and Yasuhiro Kon},
  journal={Histology and histopathology},
  year={2008},
  volume={23 4},
  pages={
          411-22
        }
}
In lupus erythematosus-prone mice, including the BXSB, NZW and NZB strains, telomeric regions of chromosome 1 (Chr.1) contain major glomerulonephritis susceptibility loci such as Bxs3, Sle1, and Nba2. To assess whether strain MRL, a model for lupus erythematosus, had glomerulonephritis susceptibility loci on Chr.1, we created B6.MRLc1(82-100) congenic mice carrying MRL/MpJ Chr.1 (82-100 cM) based on the C57BL/6 background and investigated renal pathology. From 6 months of age, B6.MRLc1 (82-100… CONTINUE READING

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