Autoimmune disorder phenotypes in Hvcn1-deficient mice.

  title={Autoimmune disorder phenotypes in Hvcn1-deficient mice.},
  author={Mari Sasaki and Akihiro Tojo and Yoshifumi Okochi and Nana Miyawaki and Daisuke Kamimura and Akihito Yamaguchi and Masaaki Murakami and Yasushi Okamura},
  journal={The Biochemical journal},
  volume={450 2},
H(v) channels (voltage-gated proton channels) are expressed in blood cells, microglia and some types of epithelial cells. In neutrophils H(v) channels regulate the production of reactive oxygen species through regulation of membrane potential and intracellular pH. H(v) channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the Hv channel at the whole-body level are not fully understood. In the present paper we show that Hvcn1 (voltage-gated… CONTINUE READING
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