Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

@article{Robinson2011AutoimmuneDR,
  title={Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.},
  author={Talin Robinson and Silvia N. Kariuki and Beverly S. Franek and Marissa Kumabe and Akaash A. Kumar and Maria Elvira Badaracco and Rachel A. Mikolaitis and Galen Guerrero and Tammy Olsen Utset and Barbara E. Drevlow and Laura S. Zaacks and James S. Grober and Lewis M. Cohen and Kyriakos A Kirou and Mary K Crow and Meenakshi Jolly and Timothy B Niewold},
  journal={Journal of immunology},
  year={2011},
  volume={187 3},
  pages={1298-303}
}
Increased IFN-α signaling is a heritable risk factor for systemic lupus erythematosus (SLE). IFN induced with helicase C domain 1 (IFIH1) is a cytoplasmic dsRNA sensor that activates IFN-α pathway signaling. We studied the impact of the autoimmune-disease-associated IFIH1 rs1990760 (A946T) single nucleotide polymorphism upon IFN-α signaling in SLE patients in vivo. We studied 563 SLE patients (278 African-American, 179 European-American, and 106 Hispanic-American). Logistic regression models… CONTINUE READING