Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.

  title={Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.},
  author={S H Rhim and Sarah E. Millar and Foster Robey and A M Luo and Ya-huan Lou and T D Yule and Patrick C. Allen and Jurrien Dean and Kenneth S Tung},
  journal={The Journal of clinical investigation},
  volume={89 1},
We describe a novel experimental system in mice for the study of ovarian autoimmune disease, a condition encountered in women with premature ovarian failure. The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes. Whereas the peptide induces both T cell and antibody responses, adoptive transfer of… CONTINUE READING
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