Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent.

  title={Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent.},
  author={Yue Wang and Lanfeng Hao and Ronald G Gill and Kevin J. Lafferty},
  volume={36 4},
Cultured BALB/c islets fail to function when transplanted into diabetic nonobese diabetic (NOD) mice; such grafted tissue is rapidly destroyed by disease recurrence. The cellular requirements for this graft damage are unclear. This study was designed to investigate the role of the L3T4+ T-lymphocyte subset in disease recurrence in the NOD mouse. L3T4+ T-lymphocytes were depleted by the in vivo administration of the L3T4-specific monoclonal antibody GK1.5. This treatment reduced the level of… CONTINUE READING

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