Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens.

@article{DurinovicBell1998AutoimmuneDT,
  title={Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens.},
  author={Ivana Durinovic-Bell{\'o}},
  journal={Autoimmunity},
  year={1998},
  volume={27 3},
  pages={159-77}
}
Type 1 diabetes (IDDM) is a T cell mediated autoimmune disease which in part is determined genetically by its association with major histocompatibility complex (MHC) class II alleles. The major role of MHC molecules is the regulation of immune responses through the presentation of peptide epitopes of processed protein antigens to the immune system. Recently it has been demonstrated that MHC molecules associated with autoimmune diseases preferentially present peptides of other endogenous MHC… CONTINUE READING