Autoimmune conditions and chronic infections in chronic lymphocytic leukemia patients at diagnosis are associated with unmutated IgVH genes.

@article{Vanura2008AutoimmuneCA,
  title={Autoimmune conditions and chronic infections in chronic lymphocytic leukemia patients at diagnosis are associated with unmutated IgVH genes.},
  author={Katrina Vanura and Trang Kim Le and Harald Esterbauer and Florentin Sp{\"a}th and Edit Porpaczy and Medhat M Shehata and Karin Eigenberger and Alexander W. Hauswirth and Cathrin Constanze Skrabs and Elisabeth Kr{\"o}mer and Ilse Schwarzinger and Berthold Streubel and Christoph F. Steininger and Christa Fonatsch and Stephan Stilgenbauer and Oswald Wagner and Alexander Gaiger and Ulrich Jaeger},
  journal={Haematologica},
  year={2008},
  volume={93 12},
  pages={1912-6}
}
Few data are available concerning the prevalence of autoimmune disease or chronic infections in chronic lymphocytic leukemia patients at diagnosis as well as their clinical outcome. We studied the frequency of such chronic conditions in relation to prognostic markers. A history of autoimmune disease or chronic infection was found in 21% of 186 chronic lymphocytic leukemia patients (12% in autoimmune diseases, 9% in chronic infections). Patients with a history of chronic stimulation were more… CONTINUE READING