Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.

@article{Dropcho1995AutoimmuneCN,
  title={Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.},
  author={Edward J. Dropcho},
  journal={Annals of neurology},
  year={1995},
  volume={37 Suppl 1},
  pages={S102-13}
}
The presence of specific antineuronal antibodies in some patients with paraneoplastic central nervous system (CNS) disorders supports the theory that these syndromes have an autoimmune etiology. The anti-Purkinje cell antibodies (APCAs) in some patients with paraneoplastic cerebellar degeneration and ovarian or breast carcinomas stain the cytoplasm of Purkinje cells. APCAs react with several distinct neuronal protein autoantigens, including proteins featuring a "leucine zipper" sequence motif… CONTINUE READING

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