Autoimmune bullous disorders

@article{Eming2006AutoimmuneBD,
  title={Autoimmune bullous disorders},
  author={R{\"u}diger Eming and M Hertl},
  journal={Clinical Chemistry and Laboratory Medicine (CCLM)},
  year={2006},
  volume={44},
  pages={144 - 149}
}
  • R. Eming, M. Hertl
  • Published 2006
  • Biology, Medicine
  • Clinical Chemistry and Laboratory Medicine (CCLM)
Abstract Bullous skin diseases represent a group of organ-specific autoimmune disorders characterised by binding of circulating autoantibodies to adhesion molecules of the epidermis and the dermo-epidermal basement membrane zone. Binding of these autoantibodies to their antigenic targets results in loss of adhesion between epidermal keratinocytes and at the level of the basement membrane zone. Chronic blisters and secondary painful erosions are the clinical hallmark of autoimmune bullous… Expand
Autoimmune bullous skin diseases. Part 2: diagnosis and therapy
  • A. Kneisel, M. Hertl
  • Medicine
  • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2011
TLDR
A state‐of‐the‐art algorithm for making the diagnosis of autoimmune bullous disorders is presented and an overview on currently available therapeutic options is provided. Expand
Detection of autoantibodies in autoimmune bullous skin diseases: can we do better?
TLDR
Indirect immunofluorescence microscopy performed on monkey esophagus can demonstrate circulating IgG autoantibodies in the serum of pemphigus patients and these screening tests have been described as the most sensitive. Expand
Serological Diagnosis of Autoimmune Blistering Diseases
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The aim of this paper is to review serological diagnostic methods in the diagnosis of autoimmune bullous diseases and to present developments in recent years. Expand
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TLDR
The importance of immunofluorescence antigen mapping is explained and the methods employed for classification and subclassification of epidermolysis bullosa are described. Expand
Comparison of Clinical Findings , Histological Findings and Findings on DIF Examination in Autoimmune Vesiculobullous Disorders
Autoimmune blistering disorders are characterized by presence of pathogenic autoantibodies directed against target antigens which are components of desmosome or adhesion complex of basement membraneExpand
Serological diagnosis of autoimmune bullous skin diseases: Prospective comparison of the BIOCHIP mosaic-based indirect immunofluorescence technique with the conventional multi-step single test strategy
TLDR
A high agreement was found between the results obtained by the BIOCHIP mosaic and the single test panel for the diagnosis of BP, PV, PF, and sera without serum autoantibodies and its diagnostic accuracy is comparable with the conventional multi-step approach. Expand
Significance of immunofluorescence in the diagnosis of autoimmune bullous dermatoses.
TLDR
This contribution provides an update of the classification of autoimmune bullous diseases and diagnostic procedures, with an emphasis on immunofluorescence findings. Expand
The Utility of the DNA Microarray Scanner to Simplify the Immunofluorescence Evaluation of Autoimmune Bullous Diseases
TLDR
A DNA microarray scanner was used as a digital fluorescence microscope to simplify the diagnosis of autoimmune bullous diseases and revealed a linear pattern along the basement membrane zone (BMZ) using anti-IgG and anti-C3 in all cases of bullous pemphigoid. Expand
Mapeo por inmunofluorescencia para el diagnóstico de epidermólisis ampollosa congénita
TLDR
The importance of immunofluorescence antigen mapping is explained and the methods employed for classification and subclassification of epidermolysis bullosa are described. Expand
Bullosis diabeticorum: is there a correlation between hyperglycemia and this symptomatology?
TLDR
The etiology of bullosis diabeticorum may be multifactorial, but this study suggests poor regulation of blood glucose levels, particularly hyperglycemia, may have a significant impact on the manifestation of this dermopathy. Expand
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References

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  • Biology, Medicine
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TLDR
Generally, decisive progress has been made in the characterization of the mechanisms of blister formation in autoimmune skin diseases, however, various aspects, including the exact contribution of steric hindrance and signal transduction for pemphigus IgG‐induced acantholysis or the fine tuning of the inflammatory cascade triggered by autoantibodies in some subepidermal blistering diseases still need to be addressed. Expand
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TLDR
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TLDR
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TLDR
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TLDR
Immunoblot analysis of bullous pemphigoid sera immunoadsorbed with a series of recombinant NC16A peptides revealed the presence of three novel autoantigenic sites that, along with the MCW-1 epitope, are clustered within the N-terminal 45 amino acid stretch ofNC16A. Expand
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TLDR
A standardized enzyme-linked immunosorbent assay utilizing the baculovirus-derived protein BV13 (extracellular domain of BPAG2 devoid of 68 amino acids at the C terminus linked to glutathione-S-transferase and 6x His tag) seems to be highly sensitive and specific in the detection of B PAG2-specific antibodies and, hence, may be useful in the diagnosis of bullous autoimmune diseases. Expand
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TLDR
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