Autoimmune atrophic gastritis—pathogenesis, pathology and management

@article{Neumann2013AutoimmuneAG,
  title={Autoimmune atrophic gastritis—pathogenesis, pathology and management},
  author={W. Neumann and E. Coss and M. Rugge and R. Genta},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2013},
  volume={10},
  pages={529-541}
}
Autoimmune gastritis is a chronic progressive inflammatory condition that results in the replacement of the parietal cell mass by atrophic and metaplastic mucosa. A complex interaction of autoantibodies against the parietal cell proton pump and sensitized T cells progressively destroy the parietal cells, inducing hypochlorhydria and then achlorhydria, while autoantibodies against the intrinsic factor impair the absorption of vitamin B12. The resulting cobalamin deficiency manifests with… Expand
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