Autoimmune T cells—not always the bad guys

@article{Novak1999AutoimmuneTC,
  title={Autoimmune T cells—not always the bad guys},
  author={Kristine Novak},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={28-28}
}
importance in the control of virus replication in vivo. However, there may be many limitations to the use of adoptive transfer as a potential immunotherapeutic strategy to potentiate and maintain a strong HIV-specific CTL response in vivo. The production of large numbers of HIV-specific CTL for infusion requires specialized laboratory skills and facilities; multiple infusions are necessary to maintain appropriate numbers of virus-specific CTL in vivo; and the transient and suboptimal antiviral… CONTINUE READING

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Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS .
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression .
Kinetics of CD4 T - cell repopulation of lymphoid tissues after treatment of HIV-1 infection .
Kinetics of CD4 T - cell repopulation of lymphoid tissues after treatment of HIV-1 infection .
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS .
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS .
Kinetics of CD4 T - cell repopulation of lymphoid tissues after treatment of HIV-1 infection .
caspase-3Gene product plays role in biological processApoptosis
They have genetically engineered a fusion protein composed of caspase-3 , an apoptosis - promoting protein , and the TAT transduction domain of HIV .
caspase-3Gene product is element in pathwayApoptosis
They have genetically engineered a fusion protein composed of caspase-3 , an apoptosis - promoting protein , and the TAT transduction domain of HIV .
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