Autoimmune T cell responses in the central nervous system

  title={Autoimmune T cell responses in the central nervous system},
  author={Joan Goverman},
  journal={Nature Reviews Immunology},
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either interferon-γ or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the pathology and clinical course of disease. New animal models show that myelin-specific CD8+ T cells can also mediate CNS… CONTINUE READING
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