Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator

@article{McLachlan2000AutoimmuneRT,
  title={Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator},
  author={Sandra M. McLachlan and Basil Rapoport},
  journal={International Reviews of Immunology},
  year={2000},
  volume={19},
  pages={587 - 618}
}
Autoimmunity to thyroid peroxidase (TPO), manifest as high affinity IgG class auto-antibodies, is the common denominator of human thyroid autoimmunity, encompassing patients with overt hyper-or hypothyroidism as well as euthyroid individuals with subclinical disease. The identification and cloning of TPO (the “thyroid microsomal antigen”) provided the critical tool for analyzing B and T cell reactivity to this major thyroid autoantigen. In particular, the availability of immunoreactive TPO… 

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TLDR
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TLDR
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TLDR
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...

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TLDR
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TLDR
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