Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator

@article{McLachlan2000AutoimmuneRT,
  title={Autoimmune Response to the Thyroid in Humans: Thyroid Peroxidase-The Common Autoantigenic Denominator},
  author={Sandra M. McLachlan and Basil Rapoport},
  journal={International Reviews of Immunology},
  year={2000},
  volume={19},
  pages={587 - 618}
}
Autoimmunity to thyroid peroxidase (TPO), manifest as high affinity IgG class auto-antibodies, is the common denominator of human thyroid autoimmunity, encompassing patients with overt hyper-or hypothyroidism as well as euthyroid individuals with subclinical disease. The identification and cloning of TPO (the “thyroid microsomal antigen”) provided the critical tool for analyzing B and T cell reactivity to this major thyroid autoantigen. In particular, the availability of immunoreactive TPO… Expand
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TLDR
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TLDR
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TLDR
There is only limited amino acid replacement in most of the TPO-specific light chains, particularly in those encoded by J proximal IGLV or IGKV genes, suggesting that a defect in receptor editing can occur during aAb generation in AITD. Expand
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TLDR
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TLDR
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TLDR
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Search for the Autoantibody Immunodominant Region on Thyroid Peroxidase: Epitopic Footprinting with a Human Monoclonal Autoantibody Locates a Facet on the Native Antigen Containing a Highly Conformational Epitope1
TLDR
A footprinting approach is used that can localize a highly conformational, discontinuous epitope on a very large molecule and provides the basis for rational guided mutagenesis studies to more fully characterize the TPO immunodominant region. Expand
Why measure thyroglobulin autoantibodies rather than thyroid peroxidase autoantibodies?
TLDR
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Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies.
TLDR
This finding, albeit from a single patient, questions previous observations of serum TgPOAb prepared by affinity chromatography and provides powerful evidence against shared, cross-reactive epitopes on 2 major thyroid autoantigens. Expand
Thyroid peroxidase autoantibodies in euthyroid subjects.
TLDR
Measuring TPO antibodies in euthyroid subjects can be used to identify subjects with increased risk for hypothyroidism and in women who wish to become pregnant and those with an increased risk per se who are pregnant, patients with other autoimmune diseases, subjects on amiodarone, lithium, or interferon-alpha, and in relatives of patients with autoimmune thyroid diseases. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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