Autoimmune Disease Classification by Inverse Association with SNP Alleles

@inproceedings{Sirota2009AutoimmuneDC,
  title={Autoimmune Disease Classification by Inverse Association with SNP Alleles},
  author={Marina Sirota and Marc A. Schaub and Serafim Batzoglou and William H Robinson and Atul J Butte},
  booktitle={PLoS genetics},
  year={2009}
}
With multiple genome-wide association studies (GWAS) performed across autoimmune diseases, there is a great opportunity to study the homogeneity of genetic architectures across autoimmune disease. Previous approaches have been limited in the scope of their analysis and have failed to properly incorporate the direction of allele-specific disease associations for SNPs. In this work, we refine the notion of a genetic variation profile for a given disease to capture strength of association with… CONTINUE READING
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