Autofluorescence and ageing: changes in ribosome accuracy and lysosome [corrected] function.

Abstract

Autofluorescence increased with decreasing proliferative capacity of fibroblast cultures. It also increased rapidly when cultures were treated with the aminoglycosides, streptomycin, paromomycin and G418, as well as with ammonium chloride. All these compounds are known to accumulate in lysosomes. Paromomycin is known to reduce proliferative capacity and… (More)

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