Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.

@article{Dlugosz1995AutocrineTG,
  title={Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.},
  author={Andrzej A Dlugosz and Christina K. Cheng and Ellen M. Kosik Williams and Nadine A Darwiche and Peter J Dempsey and Benno Mann and Ashley R. Dunn and Robert J Coffey and Stuart H. Yuspa},
  journal={Cancer research},
  year={1995},
  volume={55 9},
  pages={1883-93}
}
Autocrine epidermal growth factor receptor activation by transforming growth factor alpha (TGF alpha) has been implicated in growth stimulation during epithelial neoplasia. Using keratinocytes isolated from mice with genetic defects in TGF alpha expression, we tested whether TGF alpha is required for transformation by the v-rasHa oncogene. Introduction of v-rasHa into primary epidermal cultures using a retroviral vector stimulated growth of both control (TGF alpha +/+, BALB/c) and TGF alpha… CONTINUE READING