Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.

@article{Gutcher2011AutocrineTG,
  title={Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.},
  author={Ilona Gutcher and Moses K. Donkor and Qian Ma and Alexander Y Rudensky and Richard A Flavell and Ming O Li},
  journal={Immunity},
  year={2011},
  volume={34 3},
  pages={396-408}
}
TGF-β1 is a regulatory cytokine that has an important role in controlling T cell differentiation. T cell-produced TGF-β1 acts on T cells to promote Th17 cell differentiation and the development of experimental autoimmune encephalomyelitis (EAE). However, the exact TGF-β1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action remain unknown. Here we showed that deletion of the Tgfb1 gene from activated T cells and Treg cells, but not Treg cells alone… CONTINUE READING