Autocrine stimulation of interleukin-1 in the growth of human thyroid carcinoma cell line NIM 1.

@article{Zeki1993AutocrineSO,
  title={Autocrine stimulation of interleukin-1 in the growth of human thyroid carcinoma cell line NIM 1.},
  author={Kazuya Zeki and Yasuhiro Nakano and Nobuo Inokuchi and Ken Watanabe and Isao Morimoto and Uki Yamashita and Sumiya Eto},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 1},
  pages={127-33}
}
We reported first in this study that human thyroid cell line NIM 1 established from a patient with papillary adenocarcinoma of the thyroid associated with hypercalcemia and peripheral neutrocytosis produced interleukin (IL)-1 alpha and IL-1 beta in the culture supernatant and cell lysate as detected by murine thymocyte proliferative response and enzyme-linked immunosorbent assay. Production of IL-1 alpha and IL-1 beta was further confirmed by the demonstration of IL-1 alpha and IL-1 beta… CONTINUE READING

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