Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration.

  title={Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration.},
  author={S{\'e}rgio Luiz Vaz Dias and Koichi Hattori and Zhenping Zhu and Beate Heissig and Margaret Choy and William R. Lane and Ying Wu and Amy Chadburn and Elizabeth Hyjek and Michelle Ann Gill and Daniel J. Hicklin and Larry Witte and Malcolm A. S. Moore and Shahin Rafii},
  journal={The Journal of clinical investigation},
  volume={106 4},
Emerging data suggest that VEGF receptors are expressed by endothelial cells as well as hematopoietic stem cells. Therefore, we hypothesized that functional VEGF receptors may also be expressed in malignant counterparts of hematopoietic stem cells such as leukemias. We demonstrate that certain leukemias not only produce VEGF but also express functional VEGFR-2 in vivo and in vitro, resulting in the generation of an autocrine loop that may support leukemic cell survival and proliferation… CONTINUE READING
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