Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro.

@article{Loeser2000AutocrineSB,
  title={Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro.},
  author={Richard F. Loeser and G Shanker},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 7},
  pages={1552-9}
}
OBJECTIVE To determine the role of autocrine stimulation by insulin-like growth factor 1 (IGF-1) and IGF-2 in mediating chondrocyte survival and to determine whether chondrocytes from older individuals are more susceptible to cell death when IGF action is blocked. METHODS Survival was assessed in human and monkey chondrocytes cultured in suspension in alginate under serum-free conditions. The role of IGFs in mediating survival was determined by treating cultures with neutralizing antibodies… CONTINUE READING

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