Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

@article{Wang1996AutocrineST,
  title={Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.},
  author={Yi G. Wang and Richard M. Roman and Stephen D. Lidofsky and J. Gregory Fitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 21},
  pages={12020-5}
}
Recovery of cell volume in response to osmotic stress is mediated in part by increases in the Cl- permeability of the plasma membrane. These studies evaluate the hypothesis that ATP release and autocrine stimulation of purinergic (P2) receptors couple increases in cell volume to opening of Cl- channels. In HTC rat hepatoma cells, swelling induced by hypotonic exposure increased membrane Cl- current density to 44.8 +/- 7.1 pA/pF at -80 mV. Both the rate of volume recovery and the increase in Cl… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 132 extracted citations

ABC transporter-facilitated ATP conductive transport.

The American journal of physiology • 1999
View 5 Excerpts
Highly Influenced

Volume-activated chloride channels in mice Leydig cells

Pflügers Archiv - European Journal of Physiology • 2008
View 4 Excerpts
Highly Influenced

Extracellular ATP stimulates volume decrease in Necturus red blood cells.

American journal of physiology. Cell physiology • 1999
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…