Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

  title={Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.},
  author={Yi G. Wang and Richard M. Roman and Stephen D. Lidofsky and J. Gregory Fitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 21},
Recovery of cell volume in response to osmotic stress is mediated in part by increases in the Cl- permeability of the plasma membrane. These studies evaluate the hypothesis that ATP release and autocrine stimulation of purinergic (P2) receptors couple increases in cell volume to opening of Cl- channels. In HTC rat hepatoma cells, swelling induced by hypotonic exposure increased membrane Cl- current density to 44.8 +/- 7.1 pA/pF at -80 mV. Both the rate of volume recovery and the increase in Cl… CONTINUE READING
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