Autocrine secretion of osteopontin by vascular smooth muscle cells regulates their adhesion to collagen gels.

@article{Weintraub1996AutocrineSO,
  title={Autocrine secretion of osteopontin by vascular smooth muscle cells regulates their adhesion to collagen gels.},
  author={Andrea S. Weintraub and Cecilia M. Giachelli and Robert S Krauss and Manuela Guedes de Almeida and Matthew S. Taubman},
  journal={The American journal of pathology},
  year={1996},
  volume={149 1},
  pages={
          259-72
        }
}
Osteopontin (OPN) is a secreted protein postulated to facilitate vascular smooth muscle cell (VSMC) adhesion and migration. Rat aortic VSMC lines were isolated after infection with recombinant retroviruses harboring OPN sense and antisense constructs. All lines grew normally in monolayer culture. On three-dimensional collagen gels, normal VSMCs and lines containing sense constructs (n=15) or empty vector (n=10) attached to gel and invaded the matrix. Four of five antisense clones did not adhere… CONTINUE READING

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