Autocrine secretion--10 years later.

  title={Autocrine secretion--10 years later.},
  author={Michael B. Sporn and Anita B. Roberts},
  journal={Annals of internal medicine},
  volume={117 5},
The concept of autocrine secretion, its subsequent modifications, its application for understanding pathogenesis of disease, and its potential for developing new approaches to prevention and treatment are reviewed. Peptide growth factors (cytokines) act as local autocrine and paracrine mediators of tissue homeostasis. Many diseases, including cancer, atherosclerosis, rheumatoid arthritis, and other fibrotic diseases characterized by chronic inflammation, are associated with aberrant expression… CONTINUE READING