Autocrine role of endothelin in rat inner medullary collecting duct: inhibition of AVP-induced cAMP accumulation.

  • Donald E Kohan
  • Published 1993 in Journal of cardiovascular pharmacology


Exogenous endothelin-1 (ET-1) inhibits arginine vasopressin (AVP)-induced cAMP accumulation in the inner medullary collecting duct (IMCD). Because ET-1 is produced by and binds to specific receptors on the IMCD, the possibility exists that ET-1 is an autocrine regulator of AVP action in this nephron segment. To test this hypothesis, rat IMCD cells were… (More)


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