Autocrine release of TGF-beta by portal fibroblasts regulates cell growth.


Portal fibroblasts (PF) are a newly isolated population of fibrogenic cells in the liver postulated to play a significant role in early biliary fibrosis. Because transforming growth factor-beta (TGF)-beta is a key growth factor in fibrosis, we characterized the response of PF to TGF-beta. We demonstrate that PF produce significant amounts of TGF-beta2 and, unlike activated hepatic stellate cells (HSC), express all three TGF-beta receptors and are growth inhibited by TGF-beta1 and TGF-beta2. Fibroblast growth factor (FGF)-2, but not platelet derived growth factor (PDGF), causes PF proliferation. These data suggest a mechanism whereby HSC eclipse PF as the dominant myofibroblast population in biliary fibrosis.

Citations per Year

386 Citations

Semantic Scholar estimates that this publication has 386 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wells2004AutocrineRO, title={Autocrine release of TGF-beta by portal fibroblasts regulates cell growth.}, author={Rebecca G Wells and Emma A Kruglov and Jonathan A. Dranoff}, journal={FEBS letters}, year={2004}, volume={559 1-3}, pages={107-10} }