Autocrine regulation of protein secretion in mouse mammary epithelial cells.

@article{Blatchford1998AutocrineRO,
  title={Autocrine regulation of protein secretion in mouse mammary epithelial cells.},
  author={David R. Blatchford and K. A. K. Hendry and Colin J. Wilde},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={248 3},
  pages={761-6}
}
Milk secretion is under autocrine control by an inhibitory milk protein, named FIL (feedback inhibitor of lactation). Lactating mammary acini and epithelial cells cultured on reconstituted basement membrane (EHS matrix) with lactogenic hormones were used to study the characteristics of autocrine inhibition. FIL inhibited milk protein secretion in lactating acini, but not in epithelial cells on EHS matrix. The latter's insensitivity to FIL was due to formation of multicellular structures termed… CONTINUE READING