Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors.

@article{Piepkorn1998AutocrineRO,
  title={Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors.},
  author={Michael W. Piepkorn and Mark R. Pittelkow and Paul W. Cook},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 5},
  pages={
          715-21
        }
}
Although originally conceived as a basis for malignant cell growth, autocrine signaling networks are currently known to be activated during tissue repair and with in vitro cultivation. In human epidermal keratinocytes, activation of the epidermal growth factor receptor by cognate ligands mediates the majority of the autonomous replicative capacity of these cells and is necessary to inhibit differentiation and apoptosis. The importance of heparin-binding growth factors in activation of this… CONTINUE READING
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