Autocrine purinergic receptor signaling is essential for macrophage chemotaxis.

  title={Autocrine purinergic receptor signaling is essential for macrophage chemotaxis.},
  author={Moritz Kronlage and Jian tao Song and Lydia Sorokin and Katrin Isfort and Tanja Schwerdtle and Jens Leipziger and Bernard Robaye and Pamela B Conley and Hee-Cheol Kim and Sarah Sargin and Peter M Sch{\"o}n and Albrecht Schwab and Peter J. Hanley},
  journal={Science signaling},
  volume={3 132},
Chemotaxis, the movement of cells along chemical gradients, is critical for the recruitment of immune cells to sites of inflammation; however, how cells navigate in chemotactic gradients is poorly understood. Here, we show that macrophages navigate in a gradient of the chemoattractant C5a through the release of adenosine triphosphate (ATP) and autocrine "purinergic feedback loops" that involve receptors for ATP (P2Y(2)), adenosine diphosphate (ADP) (P2Y(12)), and adenosine (A2a, A2b, and A3… CONTINUE READING