Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation.

@article{Johnson1999AutocrinePO,
  title={Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation.},
  author={Simon R Johnson and Alan J. Knox},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={277 6},
  pages={L1109-L1117}
}
Airway smooth muscle proliferation is important in asthma and is dependent on pro- and antimitogenic factors and cell-matrix interactions. Here we show an antiproliferative effect of protease inhibitors on human airway smooth muscle due to inhibition of autocrine-derived matrix metalloproteinase (MMP)-2. Proliferation in response to fetal bovine serum, thrombin, and platelet-derived growth factor was inhibited by the broad-spectrum protease inhibitor Complete and the MMP inhibitors EDTA and Ro… CONTINUE READING

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